Fibrin Split Products FIB SPLIT

Synonyms
Allscripts (AEHR) Order Name	Fibrin Split Products
Sunrise Clinical Manager (SCM) Order Name	Fibrin Split Products
EPIC Order Name	Fibrin split products
Clinical Info
Specimen Type	Blood
Container	Blue Top Tube
Collection Instructions	Container/Tube: Light blue-top (3.2% sodium citrate) tube Specimen: 0.5 mL citrated plasma Transport Temperature: Frozen Collection Instruction: 1. If no other tube is drawn, draw a discard tube. 2. If there is a delay in transport, spin down, spin plasma again, and send citrate platelet-poor plasma. Double-centrifuged specimens are critical for accurate results as platelet contamination may cause spurious results. 3. Fill tube completely. 4. Mix by gently inverting several times. 5. Send aliquot frozen.
Transport Instructions	Frozen
Specimen Stability
Methodology	Latex Agglutination/Manual (semi-quantitative)
Days Performed	Monday through Friday
Performing Laboratory	Northwell Health Laboratories
CPT	85362
PDM	5500593
Result Interpretation <5 µg/mL Interpretation: Under normal conditions, the fibrinolytic process is localized on the fibrin clots because alpha2-antiplasmin and the plasminogen activator inhibitors prevent fibrinolysis from spreading. During disseminated intravascular coagulation (DIC), fibrinolysis spreads and becomes systemic, in which case the degradation of circulating fibrinogen will occur. Fragments that occur are very heterogeneous: products derived from fibrin, soluble completes, degradation products from fibrinogen, and from nonstabilized fibrin. An abnormal fibrinolytic and/or fibrinogenolytic activity shown by high levels of FDP in plasma can also be found in clinical states, such as eclampsia, carcinoma (promyelocytic leukemia), postoperative complications, cardiac and renal disorders, hepatic disorders, fibrinolysis, pulmonary embolism, and deep vein thrombosis (DVT). Positive result indicates the presence of FDP at a concentration ≥2.5 mg/mL. This test should not be used to rule out venous thromboembolism.
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