5HIAA w/Creatinine 24 hr UR 5HIAA

Synonyms
Allscripts (AEHR) Order Name	5HIAA w/ Creatinine 24 hr UR
Sunrise Clinical Manager (SCM) Order Name	5HIAA w/Creatinine 24 hr UR
EPIC Order Name	24 Hour Urine, 5-Hydroxyindoleacetic Acid (5-HIAA), Quantitative
Clinical Info	5-HIAA is the end product of serotonin (5-hydroxytryptophan) and tyrptophan metabolism. Patients with carcinoid tumors of the midgut, e.g., ileum, produce high concentrations of 5-HIAA. Patients with carcinoid tumors of the foregut and hindgut may produce little or no 5-HIAA or do so intermittently..
Specimen Type	Urine
Specimen Volume
Container	24hr Ur 25mL 6N HCl
Collection Instructions	Container/Tube: 24 hours urine container Specimen:10 mL aliquot of a 24-hour urine collected with 25 mL of 6N HCl (5 mL min) please indicate TV on cup Urine without preservative is acceptable if pH is below 6. Transport Temperature: Refrigerated Stability: 7 Days Room Temperature 30 Days Refrigerated Collection Instructions Collect 24-hour urine with 25 mL 6N HCl to maintain a pH ≤ 3. If no preservative is used, specimen must be stored refrigerated during collection but shipped frozen and pH must be > 6.
Transport Instructions	Refrigerated
Specimen Stability	7 Days Room Temperature 30 Days Refrigerated Keep urine refrigerated during collection if preservative is not used. Record 24-hour urine volume on t
Methodology	High Performance Liquid Chromatography (HPLC) • Electrochemical Detection
Days Performed	TAT: 2-5 Days
Performing Laboratories	Quest Diagnostics' Nichols Institute, Inc. - Chantilly
CPT	82570 83497
PDM	5901716 , 5901716
Result Interpretation 2-10 years: 8.0 mg/24 hr or less >10 years: 6.0 mg/24 hr or less Limitations: Patients with renal disease may display falsely decreased results. Urinary 5-HIAA is increased in patients with malabsorption disorders who also display a larger concentration of urinary tryptophan metabolites. Urinary 5-HIAA is increased in patients with intestinal obstruction and with some noncarcinoid islet cell tumors. Carcinoid syndrome may not cause elevated results, especially if the patient does not have diarrhea. Requires accurate 24-hour urine collection.
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