N-Methylhistamine, 24hr UR NMETHHIS24

Synonyms
Allscripts (AEHR) Order Name	N-Methylhistamine, 24hr Urine
Sunrise Clinical Manager (SCM) Order Name	N-Methylhistamine, 24hr Urine
EPIC Order Name	24 Hour Urine, N-Methylhistamine
Clinical Info	Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions using 24-hour urine collection specimens Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis
Specimen Type	Urine
Container	24hr Ur No Preserv
Collection Instructions	Container/Tube: 24 Hr urine container No preservative Specimen: 5 mL from well mixed 24 Hr urine collection (3 mL min) Transport Temperature: Refrigerated Stability: 14 Days Room Temperature 28 Days Refrigerated or Frozen Patient Preparation: Patient must not be taking monoamine oxidase inhibitors (MAOIs) or aminoguanidine as these medications increase N-methylhistamine (NMH) levels.
Transport Instructions	Refrigerated
Specimen Stability	14 Days Room Temperature 28 Days Refrigerated or Frozen Patient Preparation: Patient must not be taking monoamine oxidase inhibitors (MAOIs) or aminoguanidine as these medications increase N-methylhistamine (NMH) levels.
Methodology	N-methylhistamine: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Creatinine 24: Enzymatic Colorimetric Assay
Days Performed	TAT; 4-8 Days
Performing Laboratory	Mayo Medical Laboratories
CPT	82542 LOINC Code: 44340-8
PDM	1859099
Result Interpretation N-METHYLHISTAMINE 0-5 years: 120-510 mcg/g creatinine 6-16 years: 70-330 mcg/g creatinine >16 years: 30-200 mcg/g creatinine CREATININE Males: 930-2955 mg/24 hours Females: 603-1783 mg/24 hours Reference values have not been established for patients who are younger than 18 years of age.
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