B-cell Receptor IGH Gene Rearrangement, PCR BCL2IGH Gene

Synonyms

Allscripts (AEHR) Order Name

BCL2-IGH Gene Rearrangement

Sunrise Clinical Manager (SCM) Order Name

BCL2-IGH Gene Rearrangement

Clinical Info

Is useful for establishing clonality of B-cell neoplasms and in the identification of minimal residual disease or early recurrence in patients with a previous diagnosis of a B-cell neoplasm. It can be used in association with the immunoglobulin kappa light chain

Specimen Type

Blood, Tissue, Other

Container

Lavender-top (EDTA) tube, or Sodium Heparin (Dark Green), or
Tissue in Lymph Node Transport bottle or
Fine Needle Aspirates(FNA)

Collection Instructions

Specimen: Whole blood, bone marrow, fresh or frozen tissue, fixed-cell pellet 7 mL whole blood, 2 mL bone marrow  or 0.5 g tissue ( 3 mL whole blood min)
Collection Instructions
Do not reject specimens, send to laboratory for screening.
8 unstained sections on glass slides labeled with surgical case number (pathology report required, indicate if fixative is not formalin) Please include pathology report for frozen tissue and FFPE cases (partial/preliminary reports acceptable).
Needle washings (acceptable): in alcohol based fixative (eg. CytoLyt) are acceptable).

Transport Instructions

Room Temperature- Blood or Slides
Frozen Fresh Tissue only

Specimen Stability

Whole blood/Bone marrow Room temperature: 7 days
                                           Refrigerated: 7 days
                                           Frozen: Unacceptable
Formalin-fixed Paraffin-embedded tissue block (acceptable) Room temperature: Indefinitely
                                           Refrigerated: Indefinitely
                                           Frozen: Unacceptable
Fresh, unfixed tissue- Frozen -70 1 year

Methodology

Polymerase Chain Reaction (PCR) • Fragment Analysis

Days Performed

TAT: 6-7 Days

Performing Laboratory

Quest Diagnostics' Nichols Institute, Inc. - Chantilly

CPT

81261
84999

PDM

1859733

Result Interpretation

See Report

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

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