UGT1A1, Full Gene Sequencing UGT1

Synonyms

Allscripts (AEHR) Order Name

UGT1A1, Full Gene Sequencing

Sunrise Clinical Manager (SCM) Order Name

Uridine Diphosphate Glucuronosyltransferase (UG

Clinical Info

Identifying individuals who are at increased risk of adverse drug reactions with drugs that are metabolized by UGT1A1; especially irinotecan but also atazanavir, nilotinib, pazopanib, and belinostat
Identifying individuals with Gilbert syndrome due to the presence of homozygous UGT1A1*6 (c.211G>A, based on NM_000463.2) allele, TA7, homozygous TA8, or compound heterozygous *6, TA7 or TA8
Identifying individuals who are carriers of Gilbert syndrome due to the presence of heterozygous TA7 or TA8
This test is not useful for assessment of Crigler-Najjar syndrome.

Specimen Type

Blood

Container

Lavender Top Tube

Collection Instructions

Submit only 1 of the following specimens:
Specimen Type: Whole blood
Container/Tube: Adults: Lavender top (EDTA)
Pediatrics: Purple microtube
Specimen Adults: 3 mL( 0.45 mL min)
Pediatrics: 1 mL
Collection Instructions:
1. Invert several times to mix blood.
2. Send specimen in original tube. Do not aliquot.
Specimen Stability Information: Ambient (preferred) 9 days/Refrigerated 30 days

Specimen Type: Saliva
Patient Preparation: Patient should not eat, drink, smoke, or chew gum 30 minutes prior to collection.
Container/Tube: Saliva Swab Collection Kit
Volume: One swab
Collection Instructions: Collect and send specimen per kit instructions.
Specimen Stability Information: Ambient 30 days

Transport Instructions

Room Temperature

Specimen Stability

Whole Blood
9 Days Room Temperature
30 Days Refrigerated
Saliva
30 Days Room Temperature
Extracted DNA Frozen/Room Temperature/Refrigerated

Methodology

Polymerase Chain Reaction (PCR) followed by DNA Sequence Analysis

Days Performed

TAT 8-15 Days.

Performing Laboratory

Mayo Medical Laboratories

CPT

81404
LOINC Code 93844-9

PDM

1759385

Result Interpretation

An interpretive report will be provided.

Forms