Sirolimus(Rapamycin) RAPA

Synonyms

Allscripts (AEHR) Order Name

Sirolimus (Rapamycin) Level, Serum

Sunrise Clinical Manager (SCM) Order Name

Sirolimus (Rapamycin) Level, Serum

EPIC Order Name

Sirolimus Level

Clinical Info

Monitoring whole blood sirolimus concentration during therapy, particularly in individuals coadministered CYP3A4 substrates, inhibitors, or inducers
 
Adjusting dose to optimize immunosuppression while minimizing toxicity
 
Evaluating patient compliance

Specimen Type

Blood

Container

Lavender Top Tube

Collection Instructions

Container/Tube:  Lavender-top (EDTA) tube(s)
Specimen:  3 mL of EDTA whole blood (0.5 mL min)
Transport Temperature:  Refrigerate
Collection Instructions:  Do not centrifuge.

Transport Instructions

Refrigerate

Specimen Stability

7 days Refrigerated

Methodology

Chemilumescent Micropartiical Immunoassay(MIA)

Days Performed

Monday through Sunday
7 am- 11 pm
 
TAT 1 Day

Performing Laboratory

Northwell Health Laboratories

CPT

80195

PDM

5950700

Result Interpretation

4.5 - 14.0 ng/mL
 
Sirolimus Always Message:
Sirolimus target steady-state trough concentrations vary depending on the
type of transplant, concomitant immunosuppression, clinical/
institutional protocols, and time post-transplant. Results should
be interpreted in conjunction with this clinical information and any
physical signs/symptoms of rejection/toxicity. Testing performed
by Chemiluminescent Microparticle Immunoassay

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