Beta-Amyloid 42/40 Ratio ABeta42/40

Synonyms

ABeta42
ABeta40

Allscripts (AEHR) Order Name

Beta-Amyloid 42/40 Ratio

Sunrise Clinical Manager (SCM) Order Name

Beta-Amyloid 42/40 Ratio

EPIC Order Name

Beta-Amyloid 42/40 Ratio

Clinical Info

This LC-MS/MS assay measures beta-amyloid 40 (AB40) as well as AB42 in plasma, rather than AB42 alone. This permits the normalization of beta amyloid levels circulating in plasma in different patients. Using the ratio of beta-amyloid 42/beta-amyloid 40, improves sensitivity and specificity for detecting Alzheimer's disease.

Specimen Type

Blood

Specimen Volume

1.2 mL plasma (0.6 mL min)

Container

Lavender Top Tube

Collection Instructions

Container/Tube:  Lavender Top Tube
Specimen; 1.2 mL plasma  (0.6 mL min)
Collection Instructions; Spin and separate plasma from cells within one hour of collection.

Transport Instructions

Frozen

Specimen Stability

Unacceptable  Room Temperature
3 Days Refrigerated
32 Days Frozen

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Days Performed

TAT: 5-7 Days

Performing Laboratory

Quest Diagnostics Nichols Institute San Juan Capistrano CA

CPT

82233
82234

PDM

245767

Result Interpretation

ABeta 42 Not established pg/mL
ABeta 40 Not established pg/mL
ABeta 42/40 Ratio ≥0.170

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Forms


edit