BRAF and NRAS Mutation Analysis
Desired Epic Build
* = editable field
| Cerner Primary Mnemonic: | HLX NRAS/BRAF Tracking |
| PDM | 238470 |
| Informatics - Workgroup | Genetics |
| Synonyms * | NRAS BRAF |
| Display Name * | BRAF and NRAS Mutation Analysis |
| Specimen Sources (combined Order Entry and Specimen Navigator) * | |
| Specimen Types (combined Order Entry and Specimen Navigator) * |
Tissue
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| Body Fluids (types sent through AOEs) | |
| Specimen Navigator Specimen Types | |
| Specimen Navigator Specimen Sources | |
| Specimen Navigator Short Name | HLX NRAS/BRAF V600 Tracking |
| Ordering info (EPIC SmartText) | ASSAY DESCRIPTION: BRAF V600 mutations are associated with sensitivity to BRAF inhibitors while NRAS mutations have a prognostic value. The NRAS/BRAF Mutation assay, performed on the Biocartis Idylla™ System using exclusively FFPE samples (Slides), combines the detection of mutations in codons 12, 13, 59, 61, 117, 146 of the NRAS gene, and mutations in codon 600 (V600E/D/K/R) of the BRAF gene. LIMITATIONS: This assay is qualitative and is not intended to detect minimal residual disease. The assay does not distinguish between some variants for NRAS G13 (G13R/V), NRAS G12 (G12 A/V) and NRAS A146 (A146T/V). While the assay detects BRAF V600E, V600K, V600R and V600D mutations it does not distinguish between the different variant occurring on the same nucleotide, i.e. the V600E/D or V600K/R mutations. Mutations present below the limit of detection of the assay (5%) might not be detected |
| IP Orderable (inpatient) | Yes |
| OP Orderable (outpatient) | Yes |
| AOEs * | |
| AP AOEs | |
| Special History | No |
| Build Comments | |
| Filter * | |
| Cerner Site Restrict | |
| Cerner Results | |
Actual Epic Build 3/11/2025
| PROCEDURE ID | 184816 | ||||||||||||||||||||||||||||||
| PDM | 238470 | ||||||||||||||||||||||||||||||
| ORDER DISPLAY NAME | BRAF and NRAS Mutation Analysis | ||||||||||||||||||||||||||||||
| PROCEDURE NAME | BRAF AND NRAS MUTATION ANALYSIS | ||||||||||||||||||||||||||||||
| PROCEDURE MASTER NUMBER | LAB14286 | ||||||||||||||||||||||||||||||
| SHORT PROCEDURE NAME | BRAF AND NRAS MUTATION ANALYSIS | ||||||||||||||||||||||||||||||
| CATEGORY CODE | 21.0 | ||||||||||||||||||||||||||||||
| CATEGORY CODE RECORD NAME | LAB MOLECULAR DIAGNOSTICS ORDERABLES | ||||||||||||||||||||||||||||||
| SYNONYMS | NRAS BRAF |
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| CLINICALLY ACTIVE | Yes | ||||||||||||||||||||||||||||||
| ORDERABLE | Yes | ||||||||||||||||||||||||||||||
| PERFORMABLE | Yes | ||||||||||||||||||||||||||||||
| FILTER GENOMICS | |||||||||||||||||||||||||||||||
| REFERENCE LINK URL | https://labs.northwell.edu/epic/test/184816 | ||||||||||||||||||||||||||||||
| ORDERING INSTRUCTIONS | |||||||||||||||||||||||||||||||
| DEFAULT SPECIMEN TYPE | Tissue | ||||||||||||||||||||||||||||||
| SPECIMEN TYPE PICK LIST | Tissue | ||||||||||||||||||||||||||||||
| SPECIMEN TYPE LIST | |||||||||||||||||||||||||||||||
| OP SPECIMEN TYPE LIST | |||||||||||||||||||||||||||||||
| SPECIMEN SOURCE PICK LIST | Abdomen/Peritoneum Adrenal, Left Adrenal, Right Amputation Anus Appendix Bile Duct Bladder Bone Brain Breast, Left Breast, Right Catheter Cervix Colon Duodenum Ear, Left Ear, Right Endocervix Esophagus Fallopian Tube, Left Fallopian Tube, Right Foreign Body Gallbladder Hardware/Implants Heart Hernia Sac Hydrocele Ileum Jejunum Joint Kidney, Left Kidney, Right Larynx Liver Lung, Left Lung, Right Lymph Node Mandible Maxilla Mediastinum Meninges/Dura Muscle Nail Nasal/Nasopharynx Nerve Ocular Oropharynx Misc Ovary, Left Ovary, Right Pancreas, Body Pancreas, Head Pancreas, Tail Parathyroid, Left Parathyroid, Right Penis Pericardium Pharynx Placenta Pleura, Left Pleura, Right Product of Conception Prostate Rectum Salivary Gland, Left Salivary Gland, Right Skin Soft Tissue Spinal Cord Spleen Stomach Synovium Testis, Left Testis, Right Thyroid, Isthmus Thyroid, Left Thyroid, Right Tonsil, Left Tonsil, Right Tooth Ureter, Left Ureter, Right Urethra Uterus Vagina Vas Deferens, Right Vas Deferens, Left Vascular Vulva Adenoids Alopecia Axilla, Left Axilla, Right Bone Marrow Adenoids Bronchial, Left Bronchial, Right Diaphragm Eye, Left Eye, Right Hepatobiliary Duct Oropharynx/Throat Urine Stoma Extranodal Lymphoid Pancreatic Duct Wound Deep Wound/Skin Superficial Abscess Omentum Pancreas Pelvic Retroperitoneum Tongue Trachea |
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| SPECIMEN SOURCE DEFAULT - MALE | |||||||||||||||||||||||||||||||
| SPECIMEN SOURCE DEFAULT - FEMALE | |||||||||||||||||||||||||||||||
| SPECIMEN SOURCE LIST | |||||||||||||||||||||||||||||||
| OP SPECIMEN SOURCE LIST | |||||||||||||||||||||||||||||||
| IP LAB TEST COMPONENTS FOR REPORT | |||||||||||||||||||||||||||||||
| OP LAB TEST COMPONENTS FOR REPORT | |||||||||||||||||||||||||||||||
| ORDER QUESTIONS | ["3046700003", "3046700004", "3046700005", "3048500000"] | ||||||||||||||||||||||||||||||
| ORDER QUESTIONS RECORD NAME | NH IP LAB DISEASE NH IP LAB DISEASE STAGE NH IP LAB SPECIMEN SOURCE |
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| INPATIENT ORDER QUESTIONS | ["3046700003", "3046700004", "3046700005", "3048500000"] | ||||||||||||||||||||||||||||||
| INPATIENT ORDER QUESTIONS RECORD NAME | NH IP LAB DISEASE NH IP LAB DISEASE STAGE NH IP LAB SPECIMEN SOURCE |
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| ORDER SPECIFIC QUESTION OVERRIDE | |||||||||||||||||||||||||||||||
| INPATIENT QUESTION OVERRIDE | |||||||||||||||||||||||||||||||
| LOCATION RESTRICT LIST IP | |||||||||||||||||||||||||||||||
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| LOCATION RESTRICT LIST INCLUDE IP | |||||||||||||||||||||||||||||||
| LOCATION RESTRICT LIST OP | |||||||||||||||||||||||||||||||
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| LOCATION RESTRICT LIST INCLUDES OP | |||||||||||||||||||||||||||||||
| EDP AMB ORDER SPECIFIC QUESTIONS RECORD NAME | NH IP PATIENT COMPLETED CONSENT | ||||||||||||||||||||||||||||||
| EDP IP ORDER SPECIFIC QUESTIONS RECORD NAME | NH IP PATIENT COMPLETED CONSENT | ||||||||||||||||||||||||||||||
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| DERIVED EDP IP BUTTONS S | |||||||||||||||||||||||||||||||
| DERIVED EDP IP BUTTONS T | |||||||||||||||||||||||||||||||
| DERIVED EDP OP BUTTONS S | |||||||||||||||||||||||||||||||
| DERIVED EDP OP BUTTONS T | |||||||||||||||||||||||||||||||
| IP ORDERABLE | |||||||||||||||||||||||||||||||
| OP ORDERABLE | |||||||||||||||||||||||||||||||
| STANDARD LAB COMPONENTS | |||||||||||||||||||||||||||||||
| STANDARD LAB COMPONENTS RECORD NAME | |||||||||||||||||||||||||||||||
| COMPONENT DATA REQUIREMENT | |||||||||||||||||||||||||||||||
EPIC OP AOEs
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EPIC IP AOEs
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| EPIC Components (results - crosswalked through Cerner) | |||||||||||||||||||||||||||||||