CSF, Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay

Synonyms

  • AQP4
  • LAB11500
  • NMO/AQP4 FACS, CSF
  • NMOCSF
  • NMOFC
  • OPTIC NEURITIS ANTIBODY

Cerner Name

NMO/AQP4 FACS, CSF

Clinical Info

Mayo code: NMOFC
Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD)
Diagnosis of autoimmune AQP4 channelopathy
Distinguishing NMOSD from multiple sclerosis early in the course of disease
When the results of this assay require further evaluation, NMOTC / Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay Titer, Spinal Fluid will be performed at an additional charge.

Specimen Sources

Lumbar Puncture

Specimen Types

Cerebrospinal Fluid

Specimen Volume

3 mL CSF (2mL min)

Container

Sterile

Collection Instructions

Container/Tube: Sterile Vial
Specimen: 3 mL CSF (2mL min)
Transport Temperature: Refrigerated
Stability: 72 Hours Room Temperature
28 Days Refrigerated or Frozen

Transport Instructions

Refrigerated

Specimen Stability

72 Hours Room Temperature
28 Days Refrigerated or Frozen

Methodology

Flow Cytometry
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or
approved by the U.S. Food and Drug Administration.

Days Performed

TAT: 6 - 9 Days

Performing Laboratories

Mayo Clinic Laboratories in Rochester

CPT

86053
86053-titer if required)

PDM

1759172

Results
Component Name Base Name Common Name External Name
NMO/AQP4 FACS, CSF NMOAQP4 NMO AQP4 FACS, CSF NMO/AQP4 FACS, CSF

Result Interpretation

Reference Range: Negative
A positive value is consistent with a neuromyelitis optica spectrum disorder (NMOSD) and justifies initiation of appropriate immunosuppressive therapy at the earliest possible time. This allows early initiation and maintenance of optimal therapy.

This autoantibody is not found in healthy subjects.

Forms
Immunology LAB11500 build edit