|
CD33
CD33
Synonyms
|
|
Allscripts (AEHR) Order Name
|
Not
Orderable
|
Sunrise Clinical Manager (SCM) Order Name
|
Not Orderable
|
EPIC Order Name
|
|
Clinical Info
|
Classification of myeloid neoplasms and acute leukemias CD33 is a transmembrane protein that is a member of the sialic acid-binding immunoglobulin-like lactic (Siglec) family. The exact function of CD33 is not known, but it may be involved in cell to cell adhesion. It is not expressed on hematopoietic stem cells but is expressed on maturing myelomonocytic cells. As granulocytes mature, there is progressive down regulation of CD33. Monocytes and macrophage/histiocytic cells maintain strong expression of CD33. In normal bone marrow, weak to moderate CD33 staining is seen on granulocytic and monocytic precursors, with strong staining in scattered mast cells. CD33 staining is useful for diagnosis of myeloid neoplasms and classification of acute leukemias. A therapeutic antibody targeting CD33 (gemtuzumab/Myelotarg) is available.
|
Specimen Type
|
Tissue, Bone Marrow, Body Fluid, CSF, Blood, Swab
|
Container
|
Green Top Tube
|
Collection Instructions
|
Specimen Type: TECHONLY Supplies: Immunostain Technical Only Envelope (T693) Specimen Type: Tissue Container/Tube: Immunostain Technical Only Envelope Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block Specimen Minimum Volume: Specimen Stability Information: Specimen Type | Temperature | Time | Special Container |
---|
TECHONLY | Ambient (preferred) | | | Refrigerated | |
|
Transport Instructions
|
|
Specimen Stability
|
|
Methodology
|
Immunohistochemistry
|
Days Performed
|
Monday through Friday
|
Performing Laboratory
|
Mayo Clinic Laboratories in Rochester
|
CPT
|
88342-TC, primary 88341-TC, if additional IHC
|
PDM
|
5200180
|
Result Interpretation
|
Forms
|
|
|