Estriol, Unconjugated E3

Synonyms

Allscripts (AEHR) Order Name

Estriol Unconjugated - Serum

Sunrise Clinical Manager (SCM) Order Name

Estriol Unconjugated - Serum

EPIC Order Name

Estriol, Unconjugated

Clinical Info

Evaluate fetal distress and placental function in the management of patients facing complications such as preëclampsia, fetal growth retardation, diabetes, Rh immunization, choriocarcinoma, and hydatidiform mole. May be elevated in hydrops fetalis in the presence of a dying fetus. May be low in the presence of a living anencephalic fetus.

Specimen Type

Blood

Specimen Volume

1 mL (minimum 0.2 mL)  of serum

Container

Gold Top Tube

Collection Instructions

Container/Tube:  Red top tube(s)
Specimen:  1 mL (minimum 0.2 mL)  of serum
Transport Temperature:  Refrigerate

Transport Instructions

Refrigerate

Specimen Stability

Methodology

Immunochemiluminometric assay (ICMA)

Days Performed

Tuesday, Thursday, Sunday

Performing Laboratories

LabCorp Burlington

CPT

82677

PDM

5903850

Result Interpretation

 

Reference Interval  (ng/mL)
See table.

Gestational     Median    Central 95% Range    
   Week
    15             0.9                0.4–1.7
    16             1.2                0.5–2.3
    17             1.5                0.6–3.7
    18             1.8                 0.9–4.3
    19             2.3                 1.2–3.6
    20             2.4                 1.5–4.3
    21             3.1                  1.1–5.2

Limitations
Single values are almost impossible to interpret; trends in a series of measurements are much more important. May be low in case of placental sulfatase deficiency in the presence of a healthy baby. Other causes of decreased estriol levels include subjects living at high altitudes, anemia, severe liver disease, and a variety of drugs.1 Estriol may be increased with multiple pregnancy2 and with oxytocin.2 It is not reliable in the presence of renal disease.1,2.

Forms

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