HMGCR Antibody, IgG HMGCR Ab

Synonyms

Allscripts (AEHR) Order Name

HMGCR Antibody, IgG

Sunrise Clinical Manager (SCM) Order Name

HMGCR Antibody, IgG

EPIC Order Name

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Antibody, IgG

Clinical Info

Differential diagnosis of myositis in patients with or without statin exposure.

Specimen Type

Container

Gold Top Tube

Collection Instructions

Container/Tube: Gold top tube
Specimen: 0.5 mL serum ( 0.15 min)
Transport Temperature: Refrigerated

Transport Instructions

Refrigerated

Specimen Stability

2 Days Room Temperature
                 14 Days Refrigerated
                 1 Year Frozen

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Days Performed

TAT: 2 - 15 Days

Performing Laboratory

ARUP Laboratories

CPT

83516
 
LOINC Code: 93493-5

PDM

1959739

Result Interpretation

0-19 Units: Negative
 
IgG antibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are mainly associated with necrotizing autoimmune myopathy (NAM) in a subset of statin-treated patients. Although infrequent, these antibodies may also be observed in statin-naive patients with NAM. Strong clinical correlation is recommended in the absence of muscle fiber necrosis, elevated serum creatine kinase, perimysial pathology, and/or statin exposure.

Forms