Renal Cell Cancer Panel Ren Cancer

Synonyms

Allscripts (AEHR) Order Name

Not Orderable

Sunrise Clinical Manager (SCM) Order Name

Not Orderable

EPIC Order Name

Renal Cancer Panel

Clinical Info

1) The family history is suggestive of a predisposition to renal cancer. Although VHL, MET, FLCN, FH, TSC1 and TSC2 are the genes that are the most often associated with classic forms of hereditary renal cancer, there are several other genes that cause an increased risk of renal cancer. The OncoGeneDx Renal Cancer panel includes analysis of these genes as well as 12 other genes affecting renal cancer risk. Thus, the OncoGeneDx Renal Cancer panel offers increased clinical sensitivity compared to testing only for the most commonly associated genes. Furthermore, panel testing is more cost effective than stepwise genetic testing (for example, ordering VHL testing followed by additional genetic testing, if negative). 2) The differential diagnosis includes various hereditary cancer syndromes. For example, if the family history consists of multiple types of cancer, such as renal cancer in addition to pancreatic cancer, this may be associated with a cancer syndrome such as VHL or Lynch syndrome. 3) Genetic testing has already been ordered due to a family history suggestive of a hereditary cancer predisposition and all results have been negative. OncoGeneDx Renal Cancer Panel includes genes whose role in cancer predisposition has been described recently in addition to genes associated with classic hereditary cancer syndromes.

Specimen Type

Container

Lavender Top Tube

Collection Instructions

Container/Tube:  Lavender top tube
Specimen:  2 - 5 mL Whole Blood
Transport Temperature: Room Temperature
 
Note:   Test requires indication for testing and family history submitted  with specimen

Transport Instructions

Room Temperature

Specimen Stability

Methodology

Exon Array CGH, Next-gen Sequencing
 
Genes:
 BAP1, EPCAM, FH, FLCN, MET, MITF, MLH1, MSH2, MSH6, PMS2, PTEN, SDHB, SDHC, SDHD, TP53, TSC1, TSC2, VHL

Days Performed

Performing Laboratory

GeneDx

CPT

81403
81404
81405
81406
81407

PDM

1659884

Result Interpretation

See Report
 
TAT; 3 to 4 Weeks
 
 

Forms


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