Renin Activity, Plasma RENINACT

Synonyms

Allscripts (AEHR) Order Name

Renin Activity, Plasma

Sunrise Clinical Manager (SCM) Order Name

Renin Activity, Plasma

EPIC Order Name

Renin Activity, Plasma

Clinical Info

Specimen Type

Specimen Volume

2 mL plasma (0.8 min)

Container

Lavender Top Tube

Collection Instructions

Container/Tube: Lavender tube(EDTA)
Specimen: 2 mL plasma (0.8 min)
Transport Temperature: Frozen Plasma
Stability: Unstable Room Temperature or Refrigerated
14 Days Frozen

It is critical that the plasma be transferred and frozen as quickly as possible to prevent cryoactivation of protein to renin (which results in falsely elevated renin levels)

Patient Preparation:
In order to facilitate interpretation of test results, the patient should be taken off medications for at least three weeks prior to sample collection. Dietary sodium levels during the period prior to testing can affect renin levels. Sodium restriction tends to cause an increase in renin activity, while supplementation can result in lower values. A 24-hour urine sodium determination from a sample collected on the day before a renin test can be used to assess sodium intake. Expected renin activity levels for various levels of urinary sodium excretion are provided. Renin activity determination without the concurrent urine sodium measurement can still provide useful information if the clinician verifies that the patient has been on a normal sodium diet. Since patient posture prior to collection affects renin levels, it is recommended that the patient be ambulatory for at least 30 minutes before blood collection.1 If inpatients are physically able, they should be asked to ambulate for 30 minutes before blood is drawn for renin activity. Reference intervals are provided for patients who have ambulated for at least 30 minutes prior to collection (upright patients). Reference intervals are also provided for patients on a normal sodium diet who are unable to ambulate (supine patients).

Cause for Rejection: Non-Frozen sample;non-separated sample;non-EDTA plasma; gross icterus.

Transport Instructions

Frozen Plasma

Specimen Stability

Unstable Room Temperature or Refrigerated
14 Days Frozen

It is critical that the plasma be transferred and frozen as quickly as possible to prevent cryoactivation of protein to renin (which results in falsely elevated renin levels)

Methodology

Liquid chromatography/mass spectrometry (LC/MS-MS).

Days Performed

Performing Laboratories

LabCorp of America

CPT

84244
LOINC Code: 2915-7

PDM

5900321

Result Interpretation

Forms