Cystatin-C with GFR CYSTC

Synonyms

Allscripts (AEHR) Order Name

Cystatin-C with eGFR

Sunrise Clinical Manager (SCM) Order Name

Cystatin-C with eGFR

EPIC Order Name

Cystatin-C with eGFR

Clinical Info

Aids in the assessment of glomerular filtration rate in patients for whom serum creatinine may be misleading, such as the very obese, elderly, or malnourished patients.

Specimen Type

Blood

Container

MT Grn

Collection Instructions

Container/Tube: Gold top or Mint Green Li Heparin tube
Specimen: 1 mL serum or plasma (0.5 mL min)
Transport Temperature: Refrigerated
Stability:  7 Days Refrigerated

Transport Instructions

Refrigerated

Specimen Stability

7 Days Room Temperature
7 Days Refrigerated
24 months Frozen

Methodology

Immunoturbidimetric

Days Performed

Sunday - Saturday 24 hours a day
 
TAT same day

Performing Laboratory

Northwell Health Laboratories

CPT

82610
 
LOINC Code:  87430-5

PDM

1559167

Result Interpretation

CYSTATIN C
Males:
0 days-22 years: no reference values established
23-29 years: 0.60-1.03 mg/L
30-39 years: 0.64-1.12 mg/L
40-49 years: 0.68-1.22 mg/L
50-59 years: 0.72-1.32 mg/L
60-69 years: 0.77-1.42 mg/L
70-79 years: 0.82-1.52 mg/L
>79 years: no reference values established
Females:
0 days-22 years: no reference values established
23-29 years: 0.57-0.90 mg/L
30-39 years: 0.59-0.98 mg/L
40-49 years: 0.62-1.07 mg/L
50-59 years: 0.64-1.17 mg/L
60-69 years: 0.66-1.26 mg/L
70-80 years: 0.68-1.36 mg/L
81-86 years: 0.70-1.45 mg/L
>86 years: no reference values established
 
eGFR
>60 mL/min/BSA
eGFR will not be calculated for patients under 18 years.
 
Interpretation:
Cystatin C:
Cystatin C inversely correlates with the glomerular filtration rate (GFR), that is elevated levels of cystatin C indicate decreased GFR. Cystatin C may provide more accurate assessment of GFR for very obese, elderly, or malnourished patients than creatinine. Cystatin C equation does not require patient ethnic data, and can be used for those patients with this information unavailable.
 
Due to immaturity of renal function, cystatin C levels are higher in neonates <3 months of age.(2)
 
Estimated Glomerular Filtration Rate (eGFR):
Chronic kidney disease (CKD) is defined as the presence of: persistent and usually progressive reduction in GFR (GFR <60 mL/min/1.73 m[2]) and/or albuminuria (>30 mg of urinary albumin per gram of urinary creatinine), regardless of GFR.
 
According to the National Kidney Foundation Kidney Disease Outcome Quality Initiative (K/DOQI) classification, among patients with CKD, irrespective of diagnosis, the stage of disease should be assigned based on the level of kidney function:
 
 

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