Prostaglandin D2, 24hr urine PGD2UR24

Synonyms

Allscripts (AEHR) Order Name

Prostaglandin D2, 24hr urine

Sunrise Clinical Manager (SCM) Order Name

Prostaglandin D2, 24hr urine

EPIC Order Name

Clinical Info

Clinical Significance:
Prostaglandins are fatty acids derived from arachidonic acid metabolism. They are closely related to the Thromboxanes and Leukotrienes. Prostaglandin D2 is derived mainly from Prostaglandin H2, and is metabolized to 13,14-dihydro-15-keto Prostaglandin D2. Prostaglandin D2 is excreted directly into the urine. The sites of highest Prostaglandin D2 activity are the brain, spinal cord, intestines, and stomach.

Prostaglandin D2 is the major Prostaglandin produced by
uterine tissue. Prostaglandin D2 is a potent bronchoconstrictor, neuromodulator, and anti-thrombin agent. It also stimulates the secretion of Pancreatic Glucagon. Prostaglandin D2 has been found to have an anti-metastatic effect on many malignant tumor cells. Prostaglandin D2 production and circulating levels are drastically suppressed by aspirin and indomethacin.

Specimen Type

Urine

Specimen Volume

5-10 mL Urine (Min Volume: 1 mL)

Container

Transfer 5 – 10 ml urine to urine transport container and freeze immediately.

Collection Instructions

24 hours urine collection. Refrigerate during collection and mix well. Transfer 5 – 10 ml urine to urine transport container and freeze immediately.

Minimum sample volume: 1 ml

Patient Preparation:
Patient should not be on aspirin, indomethacin, or anti-inflammatory medications, if possible, for at least 48 hours prior to collection of specimen. 

Transport Instructions

FROZEN Temp

Specimen Stability

Rejection criteria include:
room temperature, thawed, or refrigerated specimens.

Methodology

Urine Prostaglandin D2 is measured by direct ELISA.

Days Performed

TAT:4-6 Business Days

Performing Laboratories

• Inter Science Institute

CPT

84150

PDM

265699

Result Interpretation

Forms