TPMT Enzyme TPMTENZ

Synonyms

Allscripts (AEHR) Order Name

TPMT Enzyme

Sunrise Clinical Manager (SCM) Order Name

Thiopurine Methyltransferase (TPMT) Enzy

EPIC Order Name

Thiopurine Methyltransferase (TPMT) Enzyme Activity

Clinical Info

Determination of TPMT levels that may be associated with toxicity of anticancer and anti-inflammatory drugs

Specimen Type

Blood

Container

Lavender Top Tube

Collection Instructions

Container/ Tube: 2  Lavender top (EDTA
Specimen:  8 mL Whole Blood adults
                    5 mL Whole Blood pediatric
                    Minimum: 5 mL Whole Blood
Transport Temperature: Refrigerated whole blood (Stable 14 days)

Transport Instructions

Refrigerated whole blood (Stable 14 days)

Specimen Stability

Methodology

Enzymatic endpoint/liquid chromatography/tandem mass spectrometry (LC/MS-MS).

Days Performed

Performing Laboratory

LabCorp of America

CPT

82657
 
Loinc Code: 21563-2

PDM

5906029

Result Interpretation

• Normal: 15.1−26.4 units/mL RBC
• Heterozygous for low TPMT variant: 6.3−15.0 units/mL RBC
• Homozygous for low TPMT variant: <6.3 units/mL RBC

Forms