Prostaglandin D2/Creatinine Ratio, UR PGD2UR

Synonyms

Allscripts (AEHR) Order Name

Prostaglandin D2, Random Urine

Sunrise Clinical Manager (SCM) Order Name

Prostaglandin D2, Random Urine

EPIC Order Name

Prostaglandin D2, Random Urine

Clinical Info

Clinical Significance:
Prostaglandins are fatty acids derived from arachidonic acid metabolism.  They are closely related to the Thromboxanes and Leukotrienes.  
Prostaglandin D2 is derived mainly from Prostaglandin H2 and is metabolized to Dihydroketo Prostaglandin  D2.  Prostaglandin D2 is excreted directly into the urine.  
The sites of highest Prostaglandin D2 activity are the brain, spinal cord, intestines, and stomach.  Prostaglandin D2 is the major Prostaglandin produced by 
uterine tissue.  Prostaglandin D2 is a potent bronchoconstrictor, neuromodulator, and anti-antithrombin agent.  It also stimulates the secretion of Pancreatic Glucagon. 
Prostaglandin D2 has been found to have an anti-metastatic effect on many malignant tumor cells.   
Prostaglandin D2 production and circulating levels are drastically suppressed by aspirin and indomethacin. 

Specimen Type

Urine

Specimen Volume

5-10mL of a random urine specimen should be collected and frozen immediately. .

Container

Urine Random Sterile Container

Collection Instructions

5-10mL of a random urine specimen should be collected and frozen immediately.

Specimen must remain frozen prior to and during shipping. 24-hour urine collections are not acceptable. Rejection criteria include: room temperature, thawed or refrigerated specimens or 24-hour urine collections.


Patient should not be on aspirin, indomethacin, or anti-inflammatory medications, if possible, for at least 48 hours prior to collection of specimen.

Transport Instructions

Frozen

Specimen Stability

Methodology

Urine Prostaglandin D2 is measured by direct ELISA.

Days Performed

TAT: 4-6 Business Days

Performing Laboratories

Inter Science Institute (ISI)

CPT

84150

PDM

255201

Result Interpretation

Forms