Ambry CancerNext Expanded

Synonyms

• AMBRY CANCERNEXT EXPANDED
• Hereditary Cancer
• LAB14846

Cerner Name

Ambry CancerNext Expanded

Clinical Info

Comprehensive, pan-cancer test for hereditary cancer predisposition, including genes associated with a wide range of hereditary cancers such as breast, ovarian, uterine, colorectal, gastric, pancreatic, prostate, melanoma, renal, central nervous system tumors, pheochromocytoma/paraganglioma, hematologic malignancy, and other rare cancer predisposition conditions.  77 genes are included in the analysis: AIP, ALK, APC, ATM, AXIN2, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDC73, CDH1, CDK4, CDKN1B, CDKN2A, CEBPA, CHEK2, CTNNA1, DDX41, DICER1, EGFR, EPCAM, ETV6, FH, FLCN, GATA2, GREM1, HOXB13, KIT, LZTR1, MAX, MBD4, MEN1, MET, MITF, MLH1, MSH2, MSH3, MSH6, MUTYH, NF1, NF2, NTHL1, PALB2, PDGFRA, PHOX2B, PMS2, POLD1, POLE, POT1, PRKAR1A, PTCH1, PTEN, RAD51C, RAD51D, RB1, RET, RPS20, RUNX1, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, SMARCE1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, WT1

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous Buccal

Specimen Types

Blood Swab

Specimen Volume

4mL

Container

Lavender Top Tube (EDTA whole blood) or Buccal Swab

Collection Instructions

Whole Blood

Transport Instructions

Room Temperature

Specimen Stability

72 Hours Room Temperature
7 Days Refrigerated
Buccal Swab- 6 Days Room Temperature

Methodology

Next Generation Sequencing (NGS)

Days Performed

Monday-Saturday

Performing Laboratories

• Ambry Genetics Laboratory

CPT

81432 or 81435

PDM

255308

Results

Result Interpretation

Forms