FISH Prenatal Aneuploidy CVS

Synonyms

• FISH PRENATAL ANEUPLOIDY CVS
• LAB4233

Cerner Name

FISH Prenatal Aneuploidy CVS

Clinical Info

Rapid identification of the most common chromosome syndromes in pregnancies on chorionic villus sample (CVS)
                                                
Aneuploidy Panel (CVS)
                                                                                        
 Trisomy 13 (Patau syndrome)
 Trisomy 18 (Edwards syndrome)
 Trisomy 21 (Down syndrome) 
 Sex chromosome abnormalities (X,Y)                  

Specimen Sources

Placenta

Specimen Types

Chorionic Villus

Specimen Volume

5 - 10 mg Chorionic Villi in sterile saline or transport media

Container

Sterile

Collection Instructions

Send to NSUH Cytogenetic laboratory ASAP at room temperature 20-25˚C.

Transport Instructions

 If there is a delay in transportation, store the sample in a refrigerator at 4˚C DO NOT FREEZE

NOTE: Pertinent medical information including suspected diagnosis is required and consent form.  It is required that FISH testing be performed concurrently with prenatal chromosome analysis.  

Specimen Stability

48 hours room temperature If specimen cannot be sent promptly, refrigerate and send ASAP DO NOT FREEZE

Methodology

Fluorescence in situ hybridization (FISH ) and in situ chromosome cell culturing of amniocytes to investigate numerical and/or structural chromosome abnormalities.

Days Performed

Monday to Friday

Performing Laboratories

NSUH Cytogenetic laboratory

CPT

88271 - DNA probe, each (Prenatal Aneuploidy FISH panel)
88235 - AF or CVS culture (Prenatal Aneuploidy FISH panel)
88271 - DNA probe, single (Single microdeletion FISH probe)
88275 - interphase in situ hybridization
88291 - interpretation and report

PDM

258570

Ordering Instructions

FISH testing must include Chromosome Analysis.

Results

Result Interpretation

Forms