Prostaglandin D2

Synonyms

• LAB14549
• PGD2
• PROSTAGLANDIN D2

Cerner Name

Prostaglandin D2

Clinical Info

Clinical Significance:
Prostaglandins are fatty acids derived from arachidonic acid metabolism.  They are closely related to the Thromboxanes and Leukotrienes.  
Prostaglandin D2 is derived mainly from Prostaglandin H2 and is metabolized to Dihydroketo 
Prostaglandin D2.  Prostaglandin D2 is excreted directly into the urine.  
The sites of highest Prostaglandin D2 activity are the brain, spinal cord, intestines, and stomach.  Prostaglandin D2 is the major Prostaglandin produced by uterine tissue.  Prostaglandin D2 is a potent bronchoconstrictor, neuromodulator, and anti-antithrombin agent.  It also stimulates the secretion of Pancreatic Glucagon. 
Prostaglandin D2 has been found to have an anti-metastatic effect on many malignant tumor cells.   
Prostaglandin D2 production and circulating levels are drastically suppressed by aspirin and indomethacin. 

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

3.0 mL Serum (1.0mL Minimum)

Container

Gold top Tube or Lav Top tube (EDTA Plasma)

Collection Instructions

Collection Instructions

3 ml serum or EDTA plasma should be collected and separated as soon as possible.  Freeze specimen immediately after separation.  Minimum specimen size is 1 ml.

Patient should not be on aspirin, indomethacin, or anti-inflammatory medications, if possible, for at least 48 hours prior to collection of specimen.

Transport Instructions

Frozen Temperature

Specimen Stability

Methodology

Prostaglandin D2 is measured by ELISA following extraction of specimens.

Days Performed

TAT:4-6 Business Days

Performing Laboratories

Inter science Institute (ISI)

CPT

84150

PDM

255303

Results

Result Interpretation

Forms