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Synonyms

Short Name

Procedure Master Number

Procedure ID

Clinical Info

Partial or complete deficiency of DPD activity has been associated with an increased risk for severe adverse reactions when treated with pyrimidine-based chemotherapeutic agents, such as 5-fluorouracil (5-FU). The test can also be used to confirm the clinical diagnosis of dihydropyrimidine dehydrogenase (DPD) deficiency in affected patients and for the dectection of the IVS14+1G→A mutation in asymptomatic carriers
 

Specimen Type

Container

Lavender Top Tube

Collection Instructions

Container/Tube: Lavender (EDTA) top tube or ACD solution B Yellow top tube
Specimen: 5 mL whole blood ( 3 mL min)
Transport Temperature: Room Temperature
 
Stability: 8 days Room Temperature or Refrigerated
                 Frozen Unacceptable

Transport Instructions

Room Temperature

Specimen Stability

8 days Room Temperature or Refrigerated
                 Frozen Unacceptable

Methodology

Polymerase Chain Reaction (PCR) • Single Nucleotide Primer Extension This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes

Days Performed

Monday - Thursday
 
TAT: 10 - 12 Days

Performing Laboratory

Quest Diagnostics' Nichols Institute, Inc. - Chantilly

CPT

81232
 
LOINC Code:  45284-7

PDM

1759550

Results