CSF, Myelin Oligodendrocyte Glycoprotein (MOG) Antibody with Reflex to Titer

Synonyms

  • LAB11490
  • MOG AB WITH REFLEX TO TITER, CSF
  • MOGCSF

Cerner Name

MOG Ab with Reflex to Titer, CSF

Clinical Info

Myelin Oligodendrocyte Glycoprotein (MOG) Antibody with Reflex to Titer, CSF - Neuromyelitis optica (NMO) is an inflammatory disorder predominantly affecting the optic nerves and spinal cord. Limited forms of disease including isolated optic neuritis, brainstem encephalitis and longitudinal extensive transverse myelitis (LETM) or acute disseminated encephalomyelitis (ADEM) have been referred to as NMO spectrum disorder (NMOSD). The majority of individuals with NMO and many with NMOSD have antibodies against aquaporin 4 (AQP4). MOG antibodies have been reported without AQP4 antibodies in individuals with NMO and other non-multiple sclerosis demyelinating diseases. The presence of MOG antibodies in AQP4 antibody negative individuals can help differentiate between multiple sclerosis (MS) and non-MS demyelinating diseases and aid in clinical management decisions.

Specimen Sources

Lumbar Puncture

Specimen Types

Cerebrospinal Fluid

Specimen Volume

2 mL CSF (0.5mL min)

Container

Sterile

Collection Instructions

Container/Tube: Plastic screw-cap vial
Specimen: 2 mL CSF (0.5mL min)
Transport Temperature: Refregerated
Stability: 7 Days Room Temperature
               14 Days Refrigerated
               21 Days  Frozen

Transport Instructions

Refregerated

Specimen Stability

7 Days Room Temperature
               14 Days Refrigerated
               21 Days  Frozen

Methodology

Cell-based Immunofluorescence Assay
 
If the MOG Antibody screen is positive, then a semi-quantitative titer will be performed at an additional charge (CPT code(s): 86256).
 
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Days Performed

TAT: 5-8 Days

Performing Laboratories

Quest Diagnostics' Nichols Institute, Inc. - Chantilly

CPT

86255
 
TAT 5 - 9 Days
Set up on Wednesdays

PDM

2059199

Results
Component Name Base Name Common Name External Name
MOG AB CBA, CSF MOGABCBA MOG AB CBA, CSF MOG Ab CBA, CSF
MOG AB TITER, CSF MOGAB MOG AB TITER, CSF MOG Ab Titer, CSF

Result Interpretation

MOG Ab CBA, CSF Negative
  MOG Ab Titer, CSF <1:2 titer

Forms
Immunology LAB11490 build edit