| Cerner Primary Mnemonic: | B-Type Natriuretic Peptide(BNP)ab |
| PDM | 235312 |
| Informatics - Workgroup | Chemistry |
| Synonyms * | B-Type Natriuretic Peptide(BNP)ab
BNP |
| Display Name * | B-Type Natriuretic Peptide(BNP)ab |
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| Ordering info (EPIC SmartText) | Support a diagnosis of congestive heart failure (CHF)
B-type natriuretic peptide (BNP), also referred to as brain natriuretic peptide, is a member of a family of structurally similar peptide hormones that
includes atrial natriuretic peptide.1 BNP is a 32-amino-acid peptide that contains a 17-amino-acid ring structure that is formed as the result of an
internal disulfide bond. BNP is predominantly secreted by the ventricles of the heart in response to increased pressure. BNP acts as a vasodilator
and has diuretic and natriuretic properties. BNP suppresses both sympathetic tone and the renin-angiotensin system. These physiologic effects
serve to reduce intraventricular pressure and improve the symptoms of congestive heart failure (CHF).
BNP levels increase with age and can be transiently increased by vigorous exercise.1,2 BNP levels correlate with end-diastolic pressure and tend
to be increased in patients with diminished left ventricular ejection fraction.1,3 BNP levels have been shown to be useful in the diagnosis of patients
with symptoms that are consistent with CHF. Maisel and coworkers4 found that a BNP cutoff of 75 pg/mL could be used to predict systolic and/or
diastolic abnormalities accurately in symptomatic patients referred to echocardiology for left ventricular function studies. They found that this cutoff
identified patients with abnormal function from a population of 200 patients with a sensitivity of 95.9%, specificity of 86%, positive predictive value of
98%, and a negative predictive value of 89%. The overall accuracy of the diagnosis with a cutoff of 75 pg/mL was 93%. These results were similar to
those found by Dao and coworkers.5 They found that BNP levels could be used to accurately identify patients with CHF from a population of patients
presenting at the emergency room with shortness of breath (dyspnea). They found that a BNP value >80 pg/mL could be used to identify patients with
CHF from this population with a sensitivity of 97%, specificity of 98%, positive predictive value of 92%, and a negative predictive value of 98%.6
Footnotes
1. Maisel A. B-type natriuretic peptide levels: A potential novel “white count” for congestive heart failure. J Card Fail. 2001; 7(2):183-193. PubMed 11420771
2. McNairy M, Gardetto N, Clopton P, et al. Stability of B-type natriuretic peptide levels during exercise in patients with congestive heart failure: Implications
for outpatient monitoring with B-type natriuretic peptide. Am Heart J. 2002; 143(3):406-411. PubMed 11868044
3. Valli N, Georges A, Corcuff JB, et al. Assessment of brain natriuretic peptide in patients with suspected heart failure: Comparison with radionuclide
ventriculography data. Clin Chim Acta. 2001; 306(1-2):19-26. PubMed 11282090
4. Maisel AS, Koon J, Krishnaswamy P, et al. Utility of B-natriuretic peptide as a rapid, point-of-care test for screening patients undergoing echocardiography
to determine left ventricular dysfunction. Am Heart J. 2001; 141(3):367-374. PubMed 11231433
5. Dao Q, Krishnaswamy P, Kazanegra R, et al. Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting.
J Am Coll Cardiol. 2001; 37(2):379-385. PubMed 11216950
6. Wu AH, Packer M, Smith A et al. Analytical and clinical evaluation of the Bayer ADVIA Centaur Automated B-type natriuretic peptide assay in patients
with heart failure: A multisite study. Clin Chem. 2004 May; 50(5):867-873. |
| IP Orderable (inpatient) | No |
| OP Orderable (outpatient) | No |
AOEs *
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| AP AOEs | |
| Special History | No |
| Build Comments | |
| Filter * | |
| Cerner Site Restrict | Forest Hills Hospital Laboratory
Huntington Hospital Laboratory
LabCorp
Northwell Health Laboratories
Plainview Hospital Laboratory
SIUH North Laboratory
SIUH Pouch Terminal Laboratory |
Cerner Results
| Result Desc |
Result display |
Result PDM |
| BNP |
BNP |
5901640 |
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| PROCEDURE ID |
183364 |
| PDM |
235312 |
| ORDER DISPLAY NAME |
B-Type Natriuretic Peptide(BNP) ab |
| PROCEDURE NAME |
B-TYPE NATRIURETIC PEPTIDE(BNP) AB |
| PROCEDURE MASTER NUMBER |
LAB14064 |
| SHORT PROCEDURE NAME |
B-TYPE NATRIURETIC PEPTIDE(BNP) AB |
| CATEGORY CODE |
1.0 |
| CATEGORY CODE RECORD NAME |
LAB BLOOD ORDERABLES |
| SYNONYMS |
B-Type Natriuretic Peptide(BNP)ab
BNP |
| CLINICALLY ACTIVE |
No |
| ORDERABLE |
No |
| PERFORMABLE |
Yes |
| FILTER GENOMICS |
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| REFERENCE LINK URL |
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| DEFAULT SPECIMEN TYPE |
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| SPECIMEN TYPE LIST |
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| SPECIMEN SOURCE DEFAULT - FEMALE |
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| SPECIMEN SOURCE LIST |
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| OP SPECIMEN SOURCE LIST |
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| IP LAB TEST COMPONENTS FOR REPORT |
BNP |
| OP LAB TEST COMPONENTS FOR REPORT |
BNP |
| ORDER QUESTIONS |
["3045300170", "3045300171", "3045300173"] |
| ORDER QUESTIONS RECORD NAME |
NH IP HOME COLLECT DATE
NH IP HOME COLLECT DAYS
NH IP HOME COLLECT MEDICALLY NECESSARY |
| INPATIENT ORDER QUESTIONS |
[] |
| INPATIENT ORDER QUESTIONS RECORD NAME |
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| ORDER SPECIFIC QUESTION OVERRIDE |
Yes |
| INPATIENT QUESTION OVERRIDE |
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| LOCATION RESTRICT LIST IP |
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| LOCATION RESTRICT LIST INCLUDE IP |
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| LOCATION RESTRICT LIST INCLUDES OP |
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| EDP IP ORDER SPECIFIC QUESTIONS RECORD NAME |
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| EDP IP SPECIMEN SOURCE |
Blood, Venous
Blood, Central Line
Blood, Arterial
Blood, Capillary
Blood, Peripheral |
| EDP OP SPECIMEN SOURCE |
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| EDP IP SPECIMEN TYPE |
Blood |
| EDP OP SPECIMEN TYPE |
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| IP ORDERABLE |
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| COMPONENT DATA REQUIREMENT |
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EPIC OP AOEs
| Question ID | Question Name | Question | Response Type | Response List | Require Response |
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| 3045300170 |
NH IP HOME COLLECT DATE |
Start Date |
Date |
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Yes |
| 3045300171 |
NH IP HOME COLLECT DAYS |
Days |
Custom List |
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday |
Yes |
| 3045300173 |
NH IP HOME COLLECT MEDICALLY NECESSARY |
Medically Necessary? |
Yes/No |
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Yes |
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EPIC IP AOEs
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EPIC Components (results - crosswalked through Cerner)
| Component ID | Component Name | Base Name | Common Name | External Name | Cerner Result PDM |
|---|
| 3048800683.0 |
BNP |
BNP |
BNP |
BNP |
5901640 |
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