Insulin-like Growth Factor-binding Protein 2 (IGFBP-2)
Desired Epic Build
* = editable field
| Cerner Primary Mnemonic: | Insulin Like Growth FAC II | |||||||||
| PDM | 5913800 | |||||||||
| Informatics - Workgroup | Endocrine | |||||||||
| Synonyms * | SOMATOMEDIN-C Insulin-like Growth Factor Protein 2 SOMATOMEDIN C | |||||||||
| Display Name * | Insulin-like Growth Factor-binding Protein 2 (IGFBP-2) | |||||||||
| Specimen Sources (combined Order Entry and Specimen Navigator) * | ||||||||||
| Specimen Types (combined Order Entry and Specimen Navigator) * |
Blood
|
|||||||||
| Body Fluids (types sent through AOEs) | ||||||||||
| Specimen Navigator Specimen Types | ||||||||||
| Specimen Navigator Specimen Sources | ||||||||||
| Specimen Navigator Short Name | ||||||||||
| Ordering info (EPIC SmartText) | Insulin-like growth factor II (IGF-II) is a 7.5 kilodalton, 67 amino acid peptide which is thought to mediate some of the actions of growth hormone (GH). IGF-II peptide consists of the A, C, and B chains, and is structurally homologous to IGF-I and proinsulin. IGF-II is secreted by the liver and other tissue and is postulated to have mitogenic and metabolic actions at or near the sites of synthesis; this has been termed the paracrine role of IGF-II. IGF-II also appears in the peripheral circulation, where it circulates primarily in a high molecular weight tertiary complex with IGF-binding protein-3 (IGFBP-3) and acid-labile subunit. A smaller proportion of IGF-II may circulate in association with other IGF-binding proteins. The proportion of unbound IGF-II in the circulation has been estimated at >5%. Plasma levels of IGF-II are dependent upon adequate levels of GH and other factors, including adequate nutrition. The actions of IGF-II are mediated by binding to specific cell surface receptors. The function of the type II IGF receptor is not completely defined. IGF-II binds with lower affinity to the IGF-I type receptors and the insulin receptors. These latter receptors may mediate the mitogenic and metabolic actions of IGF-II. Although its specific physiologic role has not been defined, it has been postulated that the interplay of IGF-I and IGF-II with the different cell surface receptors and circulating binding proteins modulates tissue growth. Normal postnatal plasma IGF-II levels are assumed to be at maximum levels, since administration of GH does not result in increased IGF-II levels (unlike IGF-I levels, which increase). Postnatal plasma IGF-II levels show a moderate age-related increase throughout childhood and puberty, and there is no significant variability during the day. IGF-II levels decrease in GH deficiency and in malnutrition. IGF-II levels may also decrease in acromegaly and during exogenous administration of IGF-I. | |||||||||
| IP Orderable (inpatient) | Yes | |||||||||
| OP Orderable (outpatient) | Yes | |||||||||
| AOEs * | ||||||||||
| AP AOEs | ||||||||||
| Special History | No | |||||||||
| Build Comments | ||||||||||
| Filter * | ||||||||||
| Cerner Site Restrict | AML/Quest Labs LabCorp LabCorp Lab Quest Diagnostics Sunrise Lab | |||||||||
Cerner Results
| ||||||||||
Actual Epic Build 3/11/2025
| PROCEDURE ID | 167401 | ||||||||||||||||||||||||
| PDM | 5913800 | ||||||||||||||||||||||||
| ORDER DISPLAY NAME | Insulin-like Growth Factor-binding Protein 2 (IGFBP-2) | ||||||||||||||||||||||||
| PROCEDURE NAME | INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2 (IGFBP-2) | ||||||||||||||||||||||||
| PROCEDURE MASTER NUMBER | LAB10002 | ||||||||||||||||||||||||
| SHORT PROCEDURE NAME | INSULIN LIKE 2 | ||||||||||||||||||||||||
| CATEGORY CODE | 1.0 | ||||||||||||||||||||||||
| CATEGORY CODE RECORD NAME | LAB BLOOD ORDERABLES | ||||||||||||||||||||||||
| SYNONYMS | SOMATOMEDIN-C INSULIN-LIKE GROWTH FACTOR PROTEIN 2 SOMATOMEDIN C |
||||||||||||||||||||||||
| CLINICALLY ACTIVE | Yes | ||||||||||||||||||||||||
| ORDERABLE | Yes | ||||||||||||||||||||||||
| PERFORMABLE | Yes | ||||||||||||||||||||||||
| FILTER GENOMICS | |||||||||||||||||||||||||
| REFERENCE LINK URL | https://labs.northwell.edu/epic/test/167401 | ||||||||||||||||||||||||
| ORDERING INSTRUCTIONS | |||||||||||||||||||||||||
| DEFAULT SPECIMEN TYPE | Blood | ||||||||||||||||||||||||
| SPECIMEN TYPE PICK LIST | Blood | ||||||||||||||||||||||||
| SPECIMEN TYPE LIST | |||||||||||||||||||||||||
| OP SPECIMEN TYPE LIST | |||||||||||||||||||||||||
| SPECIMEN SOURCE PICK LIST | Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous |
||||||||||||||||||||||||
| SPECIMEN SOURCE DEFAULT - MALE | Blood, Venous | ||||||||||||||||||||||||
| SPECIMEN SOURCE DEFAULT - FEMALE | Blood, Venous | ||||||||||||||||||||||||
| SPECIMEN SOURCE LIST | |||||||||||||||||||||||||
| OP SPECIMEN SOURCE LIST | |||||||||||||||||||||||||
| IP LAB TEST COMPONENTS FOR REPORT | IGF2 | ||||||||||||||||||||||||
| OP LAB TEST COMPONENTS FOR REPORT | IGF2 | ||||||||||||||||||||||||
| ORDER QUESTIONS | ["3045300170", "3045300171", "3045300173"] | ||||||||||||||||||||||||
| ORDER QUESTIONS RECORD NAME | NH IP HOME COLLECT DATE NH IP HOME COLLECT DAYS NH IP HOME COLLECT MEDICALLY NECESSARY |
||||||||||||||||||||||||
| INPATIENT ORDER QUESTIONS | [] | ||||||||||||||||||||||||
| INPATIENT ORDER QUESTIONS RECORD NAME | |||||||||||||||||||||||||
| ORDER SPECIFIC QUESTION OVERRIDE | Yes | ||||||||||||||||||||||||
| INPATIENT QUESTION OVERRIDE | |||||||||||||||||||||||||
| LOCATION RESTRICT LIST IP | |||||||||||||||||||||||||
| LOCATION RESTRICT LIST IP RECORD NAME | |||||||||||||||||||||||||
| LOCATION RESTRICT LIST INCLUDE IP | |||||||||||||||||||||||||
| LOCATION RESTRICT LIST OP | |||||||||||||||||||||||||
| LOCATION RESTRICT LIST OP RECORD NAME | |||||||||||||||||||||||||
| LOCATION RESTRICT LIST INCLUDES OP | |||||||||||||||||||||||||
| EDP AMB ORDER SPECIFIC QUESTIONS RECORD NAME | |||||||||||||||||||||||||
| EDP IP ORDER SPECIFIC QUESTIONS RECORD NAME | |||||||||||||||||||||||||
| EDP IP SPECIMEN SOURCE | Blood, Venous Blood, Central Line Blood, Arterial Blood, Capillary |
||||||||||||||||||||||||
| EDP OP SPECIMEN SOURCE | |||||||||||||||||||||||||
| EDP IP SPECIMEN TYPE | Blood | ||||||||||||||||||||||||
| EDP OP SPECIMEN TYPE | |||||||||||||||||||||||||
| DERIVED EDP IP BUTTONS S | Blood, Central Line Blood, Arterial Blood, Capillary Blood, Venous |
||||||||||||||||||||||||
| DERIVED EDP IP BUTTONS T | Blood | ||||||||||||||||||||||||
| DERIVED EDP OP BUTTONS S | |||||||||||||||||||||||||
| DERIVED EDP OP BUTTONS T | |||||||||||||||||||||||||
| IP ORDERABLE | 1 | ||||||||||||||||||||||||
| OP ORDERABLE | 1 | ||||||||||||||||||||||||
| STANDARD LAB COMPONENTS | |||||||||||||||||||||||||
| STANDARD LAB COMPONENTS RECORD NAME | |||||||||||||||||||||||||
| COMPONENT DATA REQUIREMENT | |||||||||||||||||||||||||
EPIC OP AOEs
| |||||||||||||||||||||||||
| EPIC IP AOEs | |||||||||||||||||||||||||
EPIC Components (results - crosswalked through Cerner)
| |||||||||||||||||||||||||