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HLA B57:01 Molecular Detection

Desired Epic Build * = editable field  

Cerner Primary Mnemonic: HLX HLA Antigen B5701 Case
PDM 228468
Informatics - WorkgroupMolpath inhouse
Synonyms *Abacavir Sensitivity
HLAB5701
HLA-B 5701 Genotype
HLA Antigen B5701
Abacavir hypersensitivity genotyping
Display Name *HLA B57:01 Molecular Detection
Specimen Sources (combined Order Entry and Specimen Navigator) *
Specimen Types (combined Order Entry and Specimen Navigator) *
Blood
Body Fluids (types sent through AOEs)
Specimen Navigator Specimen Types
Specimen Navigator Specimen Sources
Specimen Navigator Short Name
Ordering info (EPIC SmartText)Hypersensitivity to abacavir has been strongly associated with the HLA-B*57:01 allele. DNA-based testing to assess the presence of HLA-B*57:01 offers higher specificity than serologic testing because monoclonal antibodies may show cross-reactivity with other HLA subtypes. The U.S. Food and Drug Administration (FDA) recommends pre-therapeutic screening for the HLA-B*57:01 allele. Routine screening has been shown to reduce the incidence of ABC HSR from 8% to <0.5% in abacavir-naïve patients. Patients testing positive should not be treated with a regimen containing abacavir.
IP Orderable (inpatient) Yes
OP Orderable (outpatient) Yes
AOEs *

AP AOEs

    
Special History No 
 
    
Build Comments

    
Filter *genetics

    
    
Cerner Site Restrict

    
Cerner Results


            


     





    Actual Epic Build 3/11/2025
    






                

        PROCEDURE ID
        115147
    

        

        PDM
        228468
    

        

        ORDER DISPLAY NAME
        HLA B57:01 Molecular Detection
    

        

        PROCEDURE NAME
        HLX HLA B57-1 ANTIGEN CASE
    

        

        PROCEDURE MASTER NUMBER
        LAB11403
    

        

        SHORT PROCEDURE NAME
        HLX HLA B57-1 ANTIGEN CASE
    

        

        CATEGORY CODE
        21.0
    

        

        CATEGORY CODE RECORD NAME
        LAB MOLECULAR DIAGNOSTICS ORDERABLES
    

        

        SYNONYMS
        ABACAVIR SENSITIVITY
HLAB5701
HLA-B 5701 GENOTYPE
HLA ANTIGEN B5701
ABACAVIR HYPERSENSITIVITY GENOTYPING		
    

        

        CLINICALLY ACTIVE
        Yes
    

        

        ORDERABLE
        Yes
    

        

        PERFORMABLE
        Yes
    

        

        FILTER GENOMICS
        Generic Genomics Procedure
    

        

        REFERENCE LINK URL
        https://labs.northwell.edu/epic/test/115147
    

        

        ORDERING INSTRUCTIONS
        
Hypersensitivity to abacavir has been strongly associated with the HLA-B*57:01 allele. DNA-based testing to assess the presence of HLA-B*57:01 offers higher specificity than serologic testing because monoclonal antibodies may
 show cross-reactivity with other HLA subtypes. The U.S. Food and Drug Administration (FDA) recommends pre-therapeutic screening for the HLA-B*57:01 allele. Routine screening has been shown to reduce the incidence of ABC HSR 
from 8% to &lt;0.5% in abacavir-navØve patients. Patients testing positive should not be treated with a regimen containing abacavir.

    

        

        DEFAULT SPECIMEN TYPE
        Blood
    

        

        SPECIMEN TYPE PICK LIST
        Blood
    

        

        SPECIMEN TYPE LIST
        
    

        

        OP SPECIMEN TYPE LIST
        
    

        

        SPECIMEN SOURCE PICK LIST
        Blood, Arterial
Blood, Capillary
Blood, Central Line
Blood, Venous		
    

        

        SPECIMEN SOURCE DEFAULT - MALE
        Blood, Venous
    

        

        SPECIMEN SOURCE DEFAULT - FEMALE
        Blood, Venous
    

        

        SPECIMEN SOURCE LIST
        
    

        

        OP SPECIMEN SOURCE LIST
        
    

        

        IP LAB TEST COMPONENTS FOR REPORT
        HLXB57501
    

        

        OP LAB TEST COMPONENTS FOR REPORT
        HLXB57501
    

        

        ORDER QUESTIONS
        ["3048500000"]
    

        

        ORDER QUESTIONS RECORD NAME
        
    

        

        INPATIENT ORDER QUESTIONS
        ["3048500000"]
    

        

        INPATIENT ORDER QUESTIONS RECORD NAME
        
    

        

        ORDER SPECIFIC QUESTION OVERRIDE
        
    

        

        INPATIENT QUESTION OVERRIDE
        
    

        

        LOCATION RESTRICT LIST IP
        
    

        

        LOCATION RESTRICT LIST IP RECORD NAME
        
    

        

        LOCATION RESTRICT LIST INCLUDE IP
        
    

        

        LOCATION RESTRICT LIST OP
        
    

        

        LOCATION RESTRICT LIST OP RECORD NAME
        
    

        

        LOCATION RESTRICT LIST INCLUDES OP
        
    

        

        EDP AMB ORDER SPECIFIC QUESTIONS RECORD NAME
        NH IP PATIENT COMPLETED CONSENT
    

        

        EDP IP ORDER SPECIFIC QUESTIONS RECORD NAME
        NH IP PATIENT COMPLETED CONSENT
    

        

        EDP IP SPECIMEN SOURCE
        
    

        

        EDP OP SPECIMEN SOURCE
        
    

        

        EDP IP SPECIMEN TYPE
        
    

        

        EDP OP SPECIMEN TYPE
        
    

        

        DERIVED EDP IP BUTTONS S
        
    

        

        DERIVED EDP IP BUTTONS T
        
    

        

        DERIVED EDP OP BUTTONS S
        
    

        

        DERIVED EDP OP BUTTONS T
        
    

        

        IP ORDERABLE
        1
    

        

        OP ORDERABLE
        1
    

        

        STANDARD LAB COMPONENTS
        
    

        

        STANDARD LAB COMPONENTS RECORD NAME
        
    

        

        COMPONENT DATA REQUIREMENT
        
    

    
    
EPIC OP AOEs


                

            
Question IDQuestion NameQuestionResponse TypeResponse ListRequire Response

                        

                3048500000
                NH IP PATIENT COMPLETED CONSENT
                Patient completed consent?
                Yes/No
                
                Yes
            

                    

            


    
EPIC IP AOEs


                

            
Question IDQuestion NameQuestionResponse TypeResponse ListRequire Response

                        

                3048500000
                NH IP PATIENT COMPLETED CONSENT
                Patient completed consent?
                Yes/No
                
                Yes
            

                    

            


    
EPIC Components (results - crosswalked through Cerner)